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Heebeom Koo, Ph.D.
Education and Training
2012.04 - present: Research fellow Massachusetts General Hospital Harvard Medical School Nanosciences and Technology, KAIST Advisor: Prof. Seok-Hyun (Andy) Yun
2009.9 - 2012.04 Postdoc in Biomedical Research Center Korea institute of Science and Technology (KIST), Seoul, Korea Advisor: Dr. Kwangmeyung Kim and Dr. Ick Chan Kwon
2002.3 - 2009.9 Ph.D. in Department of Chemistry Seoul National University, Korea Advisor: Prof. Jong-sang Park
1998.3 - 2002.2 B.S. in Department of Chemistry Seoul National University, Korea
Research interests: Imaging, Drug/gene delivery, Nanoparticle, Polymer
List of publication
42. Koo H†, Lee S†, Na JH, Choi K, Kwon IC, Jeong SY, Kim K, New in vivo tumor-targeting strategy of nanoparticles via bioorthogonal copper-free click chemistry. Angew. Chem. Int. Ed., 2012, submitted (Co-first, equally contributed)
41. Ryu JH†, Koo H†, Sun IC, Yuk SH, Choi K, Kim K, Kwon IC. Tumor-targeting multi-functional nanoparticles for theragnosis: New paradigm for cancer therapy. Advanced Drug Delivery Reviews, 2012, submitted (Co-first, equally contributed)
40. Na JH, Lee SY, Koo H, Min KH, Jeong SY, Yuk SH, Kim K, Kwon IC, Effect of the stability and deformability on the tumor-targeting efficiency of self-assembled glycol chitosan nanoparticles in tumor-bearing mice, J. Controlled Release, 2012, in revision.
39. Park K, Kang JH, Sa KH, Koo H, Cho HJ, Nam EJ, Youn IC, Kim K, Kim IS, Kwon IC, Choi KW, Kang YM, Rheumatoid arthritis-homing glycol chitosan nanoparticles for early diagnosis and monitoring of therapeutic responses, Molecular imaging and biology. 2012, submitted.
38. Lee SJ, Huh MS, Lee SY, Min S, Lee S, Koo H, Lee KE, Jeon H, Choi Y, Choi K, Byun Y, Jeong SY, Park K, Kim K, Kwon IC, Tumor-homing poly-siRNA/glycol chitosan self-crosslinked nanoparticles for systemic siRNA delivery in cancer treatment, Angew. Chem. Int. Ed., 2012, accepted.
37. Lee S, LeeSY, Park S, Ryu JH, Na JH, Koo H, Lee KE, Jeon H, Kwon IC, Kim K, Jeong SY, In vivo NIRF imaging of tumor targetability of nano-sized liposomes in tumor-bearing mice. Macromolecular bioscience, 2012, accepted.
36. Noh M, Mok Y, Lee S, Kim H, Lee SH, Jin G-w, Seo JH, Koo H, Park TH, Yan Lee, Novel lower critical solution temperature phase transition materials effectively control osmosis by mild temperature change, Chemical Communications, 2012, 48(32):3845-7.
35. Koo H†, Moon H†, Han H, Na JH, Park JH, Woo SJ, Park KH, Kwon IC, Kim K, Kim H, Investigating the movement of various nanoparticles in the vitreous and retina depending on their surface properties after intravitreal injection, Biomaterials, 2012;33:3485-93. (Co-first, equally contributed)
34. Yoon HY†, Koo H†, Choi KY, Lee SJ, Kim K, Kwon IC, Leary JF, Park K, Yook SH, Park JH, Choi K, Tumor-targeting hyaluronic acid nanoparticles for in vivo photodynamic imaging and therapy in cancer treatment, Biomaterials, 2012;33:3980-9. (Co-first, equally contributed)
33. Lee DE†, Koo H†, Sun IC, Ryu JH, Kim K, Kwon IC, Multifunctional nanoparticles for multimodal imaging and theragnosis. Chem Soc Rev, 2012;41:2656-72. (Co-first, equally contributed)
32. Yhee JY, Kim SA, Koo H, Son S, Ryu JH, Youn I-C, Choi K, Kwon IC, Kim K, Optical imaging of cancer-related proteases using near-infrared fluorescence matrix metalloproteinase-sensitive and cathepsin B-sensitive probes. Theranostics, 2012;2:179-89.
31. Cho H-J, Yoon I-S, Yoon HY, Koo H, Jin Y-J, Ko S-H, et al. Polyethylene glycol-conjugated hyaluronic acid-ceramide self-assembled nanoparticles for targeted delivery of doxorubicin. Biomaterials. 2012;33:1190-200.
30. Min HS, Kang E, Koo H, Choi Y, Lee J, Kim K, Park RW, Kim IS, Kwon IC, Han M, Gas-generating polymeric microspheres for long-term and continuous in vivo ultrasound imaging. Biomaterials, 2012;33:936-44.
29. Koo H†, Huh MS†, Sun I-C, Yuk SH, Choi K, Kim K, Kwon IC, In vivo targeted delivery of nanoparticles for theranosis, Accounts of Chemical Research, 2011, 2011;44:1018-28., (Co-first, equally contributed)
28. Sun IC, Eun DK, Koo H, Ko CY, Kim HS, Yi DK, Kwon IC, Kim K, Ahn CH, Tumor targeting gold nanoparticles for CT/optical dual cancer imaging. Angew. Chem. Int. Ed., 2011;50:9348-51.
27. Ryu JH, Kim SA, Koo H, Yhee JY, Lee A, Na JH, Choi K, Kwon IC, Kim BS, Kim K, Cathepsin B-sensitive nanosensor for in vivo tumor diagnosis. Journal of Materials Chemistry. 2011;21:17631-4.
26. Ryu JH, Lee A, Chu JU, Koo H, Ko CY, Kim HS, Yoon SY, Kim BS, Choi K, Kwon IC, Kim K, Youn I. Early diagnosis of rheumatoid arthritis in collagen-induced arthritis mice using fluorogenic matrix metalloproteinase-3-specific polymeric probe. Arthritis & Rheumatism. 2011;63:3824-32.
25. Yuk SH, Oh KS, Koo H, Jeon H, Kim K, Kwon IC. Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs. Biomaterials. 2011;32:7924-31.
24. Lee SJ†, Koo H†, Jeong H, Huh MS, Choi Y, Jeong SY, Byun Y, Choi K, Kim, K, Kwon IC, Comparative study of photosensitizer loaded and conjugated glycol chitosan nanoparticles for cancer therapy, J. Controlled Release, 2011, 2011;152:21-9. (Co-first, equally contributed)
23. Lee SJ†, Koo H†, Lee D-E, Min S, Lee S, Chen X, Choi Y, Leary JF, Park K, Jeong SY, Kwon IC, Kim K, Choi K, Tumor-homing photosensitizer-conjugated glycol chitosan nanoparticles for synchronous photodynamic imaging and therapy based on cellular on/off system. Biomaterials, 2011, 32 (2011) 4021-4029. (Co-first, equally contributed)
22. Koo H†, Huh MS†, Ryu JH, Lee D-E, Sun I-C, Choi K, Kim K, Kwon IC, Nanoprobes for biomedical imaging in living systems. Nano Today, 6 (2011) 204-220., (Co-first, equally contributed)
21. Yhee J, Koo H, Lee D, Choi K, Kwon I, Kim K. Multifunctional Chitosan Nanoparticles for Tumor Imaging and Therapy, Advances in Polymer Science. 2011;243:139-61.
20. Lee DE, Kim AY, Saravanakumar G, Koo H, Kwon IC, Choi K, Park JH, Kim K, Hyaluronidase-sensitive SPIONs for MR/optical dual imaging nanoprobes. Macromolecular Research, 2011;19:861-7.
19. Jeong H, Huh MS, Lee SJ, Koo H, Kwon IC, Jeong SY, Kim K, Theranostics 2011; 1: 230-239.
18. Cho H-J, Yoon HY, Koo H, Ko S-H, Shim J-S, Lee J-H, et al. Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel. Biomaterials. 2011;32:7181-90.
17. Na JH, Koo H, Lee S, Min KH, Park K, Yoo H, Lee SH, Park JH, Kwon IC, Jeong SY, Kim K, Real-time and non-invasive optical imaging of tumor-targeting glycol chitosan nanoparticles in various tumor models, Biomaterials, 2011, 32 (2011) 5252-5261.
16. Jin G-w, Koo H, Nam K, Kim H, Lee S, Park J-S, Lee Y, PAMAM dendrimer with a 1,2-diaminoethane surface facilitates endosomal escape for enhanced pDNA delivery. Polymer. 2011;52:339-46.
15. Lee S, Choi KY, Chung H, Ryu JH, Lee A, Koo H, Youn I-C, Park J H, Kim I-S, Kim SY, Chen X, Jeong SY, Kwon IC, Kim K, Choi K, Real Time, High Resolution Video Imaging of Apoptosis in Single Cells with a Polymeric Nanoprobe. Bioconj Chem. 2011;22:125-31.
14. Yi DK, Sun I-C, Ryu JH, Koo H, Park CW, Youn I-C, Choi K, Kwon I C, Kim K, Ahn C-H, Matrix Metalloproteinase Sensitive Gold Nanorod for Simultaneous Bioimaging and Photothermal Therapy of Cancer. Bioconj Chem. 2010;21:2173-7.
13. Ko JY, Park S, Lee H, Koo H, Kim MS, Choi K, Kwon IC, Jeong SY, Kim K, Lee DS, pH-Sensitive Nanoflash for Tumoral Acidic pH Imaging in Live Animals. Small. 2010;6:2539-44.
12. Sun I-C, Lee S, Koo H, Kwon IC, Choi K, Ahn C-H, Kim K, Caspase Sensitive Gold Nanoparticle for Apoptosis Imaging in Live Cells. Bioconj Chem. 2010;21:1939-42.
11. Koo H†, Lee H†, Lee S, Min KH, Kim MS, Lee DS, Choi Y, Kwon, IC, Kim, K, Jeong SY, In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles. Chem Commun. 2010;46:5668-70. (Co-first, equally contributed) (Introduced in ‘Highlights in Chemical Biology’ of RSC)
10. Wu XL, Kim JH, Koo H, Bae SM, Shin H, Kim MS, Lee, BH, Park, RW, Kim, IS, Choi K, Kwon IC, Kim K, Lee DS, Tumor-Targeting Peptide Conjugated pH-Responsive Micelles as a Potential Drug Carrier for Cancer Therapy. Bioconj Chem. 2010;21:208-13.
9. Koo H†, Jin G-w†, Kang H, Lee Y, Nam K, Zhe Bai C, Park JS, Biodegradable branched poly(ethylenimine sulfide) for gene delivery. Biomaterials. 2010;31:988-97. (Co-first, equally contributed)
8. Koo H, Jin G.W, Park JS, In vitro Gene Delivery to HepG2 cells with a Novel Galactosylated Polyornithine, B KOR CHEM SOC, 2009, 30(7), 1622-1624
7. Koo H, Jin G-w, Kang H, Lee Y, Nam HY, Jang H-s, Park JS, A new biodegradable crosslinked polyethylene oxide sulfide (PEOS) hydrogel for controlled drug release. Int J Pharm. 2009;374:58-65.
6. Koo H, Kang H, Lee Y, Analysis of the Relationship between the Molecular Weight and Transfection Efficiency/Cytotoxicity of Poly-L-arginine on a Mammalian Cell Line, B KOR CHEM SOC, 2009, 30(4), 927-930
5. Lee Y, Cho MY, Mo H, Nam K, Koo H, Park JS, “Enhancement of the Transfection Efficiency of Poly(ethylenimine) by Guanidylation” , B KOR CHEM SOC, 2008, 29(3), 666-668
4. Lee Y, Mo H, Koo H, Park JY, Cho MY, Jin GW, Park JS, Visualization of the degradation of a disulfide polymer, linear poly(ethylenimine sulfide), for gene delivery. Bioconjug Chem. 2007;18:13-8. (Editor selected papers in Bioconjug Chem.)
3. Koo H, Jin GW, Lee Y, Mo H, Cho MY, Park JS, “Synthesis of Poly(ethylene oxide sulfide) with Large Molecular Weight by O2 Gas Oxidation “, B KOR CHEM SOC, 2005, 26(12), 2069-2071
2. Lee Y, Koo H, Jin G-w, Mo H, Cho MY, Park J-Y, Park JS Poly(ethylene oxide sulfide): New Poly(ethylene glycol) Derivatives Degradable in Reductive Conditions. Biomacromolecules. 2004;6:24-6.
1. Lee Y, Koo H, Lim Y-b, Lee Y, Mo H, Sang Park J. New cationic lipids for gene transfer with high efficiency and low toxicity: T-shape cholesterol ester derivatives. Bioorg Med Chem Lett. 2004;14:2637-41.
Patent
Kwon IC, Kim K, Choi K,Youn IC, Koo H, Lee S. Method for in vivo targeting of nanoparticles via bioorthogonal copper-free click chemistry. Applied number: 10-2012-0028370, (Korea patent, 20. Mar. 2012).
Book Chapter
Koo H, Choi K, Kwon IC, Kim K. Chitosan based nanoparticles for biomedical application. In; Yoon Y, editor. Nanopartuculated drug delivery systems: Strategies, Technologies, and Applications. John Wiley & Sons, Inc. (submitted) |
